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Hydroxyzine Injection and Renal/liver disease

Result of checking the interaction of drug Hydroxyzine Injection and disease Renal/liver disease for safety when used together.

Check result:

Hydroxyzine Injection <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Limited pharmacokinetic data are available for the older, first-generation antihistamines. Many appear to be primarily metabolized by the liver, and both parent drugs and metabolites are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from antihistamines due to drug and metabolite accumulation. Therapy with antihistamines should be administered cautiously in such patients. Lower initial dosages may be appropriate.

References:

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Hydroxyzine Injection

Generic Name: hydroxyzine

Brand Name: ANX, Vistaril, Atarax, Vistaril IM, Hyzine, Vistaject-50, Rezine

Synonyms: Hydroxyzine, HydrOXYzine

What is Hydroxyzine Injection?

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Hydroxyzine Injection <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Some anxiolytics, sedatives and hypnotics are extensively metabolized by the liver, and excreted in the urine. Patients with impaired renal and/or hepatic function may be at greater risk for adverse effects, including central nervous system and respiratory depression, due to drug and metabolite accumulation. Therapy with these drugs should be administered cautiously in such patients, with careful dose selection usually starting at the low end of the dosing range.

References: