Drug search by name

Hydroxyzine Injection and Anticholinergic effects

Result of checking the interaction of drug Hydroxyzine Injection and disease Anticholinergic effects for safety when used together.

Check result:

Hydroxyzine Injection <> Anticholinergic effects

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Antihistamines often have anticholinergic activity, to which elderly patients are particularly sensitive. Therapy with antihistamines should be administered cautiously, if at all, in patients with preexisting conditions that are likely to be exacerbated by anticholinergic activity, such as urinary retention or obstruction; angle-closure glaucoma, untreated intraocular hypertension, or uncontrolled primary open-angle glaucoma; and gastrointestinal obstructive disorders. Conventional, first-generation antihistamines such as the ethanolamines (bromodiphenhydramine, carbinoxamine, clemastine, dimenhydrinate, diphenhydramine, doxylamine, phenyltoloxamine) tend to exhibit substantial anticholinergic effects. In contrast, the newer, relatively nonsedating antihistamines (e.g., cetirizine, fexofenadine, loratadine) reportedly have low to minimal anticholinergic activity at normally recommended dosages and may be appropriate alternatives.

References:

"Product Information. Optimine (azatadine)." Schering Laboratories, Kenilworth, NJ.
"Product Information. Periactin (cyproheptadine)." Merck & Co, Inc, West Point, PA.
"Product Information. Drixoral (dextromethorphan)." Schering-Plough, Liberty Corner, NJ.
"Product Information. Marezine (cyclizine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Zyrtec (cetirizine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Benadryl (diphenhydramine)." Parke-Davis, Morris Plains, NJ.
"Product Information. Semprex-D (acrivastine-pseudoephedrine)." Endo Laboratories LLC, Chadds Ford, PA.
"Product Information. Dramamine (dimenhydrinate)" Pharmacia and Upjohn, Kalamazoo, MI.
Watemberg NM, Roth KS, Alehan FK, Epstein CE "Central anticholinergic syndrome on therapeutic doses of cyproheptadine." Pediatrics 103 (1999): 158-60
"Product Information. Phenergan (promethazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Schuller DE, Turkewitz D "Adverse effects of antihistamines." Postgrad Med 79 (1986): 75-86
"Product Information. Vistaril (hydroxyzine)." Pfizer US Pharmaceuticals, New York, NY.
"Product Information. Dimetane (brompheniramine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
DiPiro JT, Talbert RL, Yee GC, Matzke GR, Wells BG, Posey LM "Pharmacotherapy: A Pathophysiologic Approach 4th" Stamford, CT: Appleton & Lange (1999):
"Product Information. Chlortrimeton (chlorpheniramine)." Schering-Plough, Liberty Corner, NJ.
"Product Information. Tacaryl (methdilazine)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Tavist (clemastine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Antivert (meclizine)." Roerig Division, New York, NY.
"Product Information. Temaril (trimeprazine)" Allergan Inc, Irvine, CA.
"Product Information. Poly-Histine-D (pyrilamine)." Bock Pharmaceutical Company, St. Louis, MO.