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Hydrochlorothiazide and propranolol and Renal impairment

Result of checking the interaction of drug Hydrochlorothiazide and propranolol and disease Renal impairment for safety when used together.

Check result:

Hydrochlorothiazide and propranolol <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Propranolol plasma clearance was reduced in patients with chronic renal failure. Chronic renal failure has been associated with a decrease in drug metabolism via downregulation of hepatic cytochrome P450 activity resulting in a lower "first-pass" clearance; therefore, therapy with propranolol should be administered cautiously in patients with impaired renal function. Propranolol is not significantly dialyzable.

Hydrochlorothiazide and propranolol

Generic Name: hydrochlorothiazide / propranolol

Brand Name: Inderide, Inderide LA

Synonyms: Propranolol and Hydrochlorothiazide

What is Hydrochlorothiazide and propranolol?