Hycamtin (Topotecan Capsules) and Renal dysfunction
Result of checking the interaction of drug Hycamtin (Topotecan Capsules) and disease Renal dysfunction for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Topotecan is partially eliminated by the kidney. Approximately 30% of topotecan is excreted in the urine. Plasma clearance of topotecan was reduced 33% in patients with mild renal impairment (creatinine clearance of 40 to 60 mL/min) and 66% in patients with moderate renal impairment (creatinine clearance of 20 to 40 mL/min). Therapy with topotecan should be administered cautiously and at a reduced dosage in patients with moderate to severe renal dysfunction.
- "Product Information. Hycamtin (topotecan)." SmithKline Beecham, Philadelphia, PA.
Generic Name: topotecan
Brand Name: Hycamtin
Synonyms: Hycamtin (oral/injection), Hycamtin