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Hycamtin (Topotecan Capsules) and Bleeding disorders

Generic Name: topotecan
Dosage Forms: injection, powder, lyophilized, for solution
Other Brand Names: Hycamtin

Result of checking the interaction of drug Hycamtin (Topotecan Capsules) and disease Bleeding disorders for safety when used together.

Check result:

Hycamtin (Topotecan Capsules) <> Bleeding disorders

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Topotecan induces myelosuppression. Severe thrombocytopenia (< 25,000/mm3) has been reported during topotecan therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bleeding such as petechiae, purpura, hematuria, or melena. Close clinical monitoring of hematopoietic function is recommended. Therapy with topotecan should not be initiated in patients with platelet counts < 100,000/mm3. Subsequent courses of topotecan should be withheld until platelet counts exceed 100,000/mm3.

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