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Guanfacine Tablets and Renal/liver disease

Result of checking the interaction of drug Guanfacine Tablets and disease Renal/liver disease for safety when used together.

Check result:

Guanfacine Tablets <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Normally, approximately 50% of a guanfacine dose is eliminated unchanged by the kidney and the rest metabolized by the liver. However, neither the parent drug nor its metabolites accumulate significantly during chronic dosing in patients with severe renal impairment due to increased hepatic metabolism of the drug in these patients. Thus, initial dosage adjustments are generally not necessary in renal impairment. Dosage titration, however, should be made cautiously if hepatic function is also compromised. The pharmacokinetics of guanfacine has not been studied in patients with liver disease. The manufacturer recommends caution when the drug is used in such patients.

References:

Kirch W, Kohler H, Braun W "Elimination of guanfacine in patients with normal and impaired renal function." Br J Clin Pharmacol 10 (1980): s33-5
Kiechel JR "Pharmacokinetics and metabolism of guanfacine in man: a review." Br J Clin Pharmacol 10 (1980): s25-32
Kirch W, Kohler H, Braun W, von Gizycki C "The influence of renal function on plasma concentration, urinary excretion and antihypertensive effect of guanfacine." Clin Pharmacokinet 5 (1980): 476-83
Kiechel JR "Pharmacokinetics of guanfacine in patients with impaired renal function and in some elderly patients." Am J Cardiol 57 (1986): e18-21
Carchman SH, Sica DA, Davis J, Crowe JT, Jr Wasserman AJ, Proctor JD, Wright GJ "Steady-state plasma levels and pharmacokinetics of guanfacine in patients with renal insufficiency." Nephron 53 (1989): 18-23
"Product Information. Tenex (guanfacine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

Guanfacine Tablets

Generic Name: guanfacine

Brand Name: Intuniv, Tenex

Synonyms: Guanfacine, GuanFACINE

What is Guanfacine Tablets?