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Glipizide and metformin and B12 deficiency

Result of checking the interaction of drug Glipizide and metformin and disease B12 deficiency for safety when used together.

Check result:

Glipizide and metformin <> B12 deficiency

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Metformin may interfere with vitamin B12 (cyanocobalamin) absorption from the B12-intrinsic factor complex. A decrease to subnormal levels of previously normal serum B12 levels has been reported in approximately 7% of patients treated with metformin during controlled clinical trials. Although the decrease is generally well-tolerated and rarely associated with clinical manifestations such as megaloblastic anemia, caution may be warranted when metformin therapy is administered in patients with preexisting B12 deficiency. Vitamin B12 supplementation as well as annual measurements of hematologic parameters may be appropriate.

References:

Deutsch JC, Santhosh-Kumar CR, Kolhouse JF "Efficacy of metformin in non-insulin-dependent diabetes mellitus." N Engl J Med 334 (1996): 269
Callaghan TS, Hadden DR, Tomkin GH "Megaloblastic anaemia due to vitamin B12 malabsorption associated with long-term metformin treatment." Br Med J 280 (1980): 1214-5
Stowers JM, Smith OA "Vitamin B 12 and metformin." Br Med J 3 (1971): 246-7
Tomkin GH "Metformin and B 12 malabsorption." Ann Intern Med 76 (1972): 668
Tomkin GH, Hadden DR, Weaver JA, Montgomery DA "Vitamin-B12 status of patients on long-term metformin therapy." Br Med J 2 (1971): 685-7
"Product Information. Glucophage (metformin)." Bristol-Myers Squibb, Princeton, NJ.

Glipizide and metformin

Generic Name: glipizide / metformin

Brand Name: Metaglip

Synonyms: Glipizide and Metformin

What is Glipizide and metformin?