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Gleostine and Renal dysfunction

Result of checking the interaction of drug Gleostine and disease Renal dysfunction for safety when used together.

Check result:

Gleostine <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Renal abnormalities such as azotemia, and progressive decline in renal function have been reported after prolonged therapy with large doses of carmustine and lomustine. Lower total doses have also resulted in kidney damage. Therapy with carmustine or lomustine should be administered cautiously in patients with a history of or predisposition to renal dysfunction. Clinical monitoring of renal function is recommended.

References:

Seffart G ed. "Drug Dosage in Renal Insufficiency." Dordrecht, South Holland, : Kluwer Academic Publishers (1991):
"Product Information. BiCNU (carmustine)." Bristol-Myers Squibb, Princeton, NJ.
Weiss RB, Poster DS "THE RENAL TOXICITY OF CANCER CHEMOTHERAPEUTIC AGENTS." Cancer Treat Rev 9 (1982): 37-561982
"Product Information. CeeNU (lomustine)." Bristol-Myers Squibb, Princeton, NJ.
Ellis ME, Weiss RB, Kuperminc M "Nephrotoxicity of lomustine. A case report and literature review." Cancer Chemother Pharmacol 15 (1985): 174-5

Gleostine

Generic Name: lomustine

Brand Name: Gleostine, Ceenu

Synonyms: n.a.

What is Gleostine?