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Gleostine and Pulmonary infiltrates/fibrosis

Generic Name: lomustine
Dosage Forms: capsule, gelatin coated
Other Brand Names: Gleostine , Ceenu

Result of checking the interaction of drug Gleostine and disease Pulmonary infiltrates/fibrosis for safety when used together.

Check result:

Gleostine <> Pulmonary infiltrates/fibrosis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Pulmonary infiltrates and/or fibrosis have been reported during lomustine therapy. Toxicity occurred after 6 months of cumulative doses usually > 1100 mg/m2. Late reduction in pulmonary function, progressive fibrosis, and death have been noted. It is recommended to permanently discontinue therapy in patients diagnosed with pulmonary fibrosis. Therapy with lomustine should be administered cautiously in patients with preexisting pulmonary dysfunction. Pulmonary function studies prior to and during therapy are recommended.

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