Drug search by name

Gengraf Capsules and Hepatic dysfunction

Result of checking the interaction of drug Gengraf Capsules and disease Hepatic dysfunction for safety when used together.

Check result:

Gengraf Capsules <> Hepatic dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cyclosporine is extensively metabolized by CYP450 3A enzymes in the liver (some GI and renal metabolism) and primarily eliminated in the bile and feces. Cyclosporine can induce dose-related nephrotoxicity and hepatotoxicity. Hepatotoxicity, usually noted during the first month of therapy (high dosages) is characterized by elevations of hepatic enzymes and bilirubin. Reduction in chemistry levels usually results with dosage reduction. Therapy with cyclosporine should be administered cautiously and dosages modifications considered in patients with or predisposed to hepatic dysfunction. Clinical monitoring of hepatic function, particularly during administration of high dosages, is recommended.

References:

"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Tredger JM "Using cyclosporine neoral immediately after liver transplantation." Ther Drug Monit 17 (1995): 638-41
Sewing K-F, Christians U, Kohlhaw K, et al "Biologic activity of cyclosporine metabolites." Transplant Proc 22 (1990): 1129-34
de Groen PC, McCallum DK, Moyer TP, Wiesner RH "Pharmacokinetics of cyclosporine in patients with primary biliary cirrhosis." Transplant Proc 20 (1988): 509-11
Christians U, Kohlhaw K, Budniak J, et al "Ciclosporin metabolite pattern in blood and urine of liver graft recipients." Eur J Clin Pharmacol 41 (1991): 285-90
"Product Information. Neoral Oral Solution (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Kassianides C, Nussenblatt R, Palestine AG, et al "Liver injury from cyclosporine A." Dig Dis Sci 35 (1990): 693-7
Awni WM, Kasiske BL, Heim-Duthoy K, Rao KV "Long-term cyclosporine pharmacokinetic changes in renal transplant recipients: effects of binding and metabolism." Clin Pharmacol Ther 45 (1989): 41-8
Vernillet L, Moulin B, Dadoun C, et al "Pharmacokinetics of cyclosporine A in patients with nephrotic syndrome." Transplant Proc 20 (1988): 529-35
Takaya S, Zaghloul I, Iwatsuki S, et al "Effect of liver dysfunction on cyclosporine pharmacokinetics." Transplant Proc 19 (1987): 1246-7

Gengraf Capsules

Generic Name: cyclosporine

Brand Name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?