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Gemcitabine and Myelosuppression

Result of checking the interaction of drug Gemcitabine and disease Myelosuppression for safety when used together.

Check result:

Gemcitabine <> Myelosuppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Gemcitabine induces dose-related myelosuppression. Leukopenia, thrombocytopenia, and anemia have been reported during gemcitabine therapy. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Therapy should be administered cautiously and dosage modification considered in patients with bone marrow suppression. Close clinical monitory of hematopoietic function is recommended.

References:

"Product Information. Gemzar (gemcitabine)." Lilly, Eli and Company, Indianapolis, IN.
Guchelaar HJ, Richel DJ, Vanknapen A "Clinical, toxicological and pharmacological aspects of gemcitabine." Cancer Treat Rev 22 (1996): 15-31
Abratt RP, Bezwoda WR, Falkson G, Goedhals L, Hacking D, Rugg TA "Efficacy and safety profile of gemcitabine in non-small-cell lung cancer: a phase II study." J Clin Oncol 12 (1994): 1535-40

Gemcitabine

Generic Name: gemcitabine

Brand Name: Gemzar, Infugem

Synonyms: n.a.

What is Gemcitabine?