Drug search by name

Fosamax Plus D and Renal dysfunction

Result of checking the interaction of drug Fosamax Plus D and disease Renal dysfunction for safety when used together.

Check result:

Fosamax Plus D <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Ergocalciferol, cholecalciferol, and calcifediol undergo renal biotransformation during metabolic activation. Renal impairment can alter metabolic and therapeutic activity of certain vitamin D analogs. Alternative vitamin D analogs such as dihydrotachysterol (hepatic activation) and calcitriol (active form) may be considered in patients with compromised renal function.

References:

"Product Information. Calciferol (ergocalciferol)." Schwarz Pharma, Mequon, WI.
"Product Information. Calderol (calcifediol)." Organon, West Orange, NJ.
"Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.

Fosamax Plus D

Generic Name: alendronate / cholecalciferol

Brand Name: Fosamax Plus D

Synonyms: n.a.

What is Fosamax Plus D?

Another drug Delete

Fosamax Plus D <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

Consumer:

Alendronate is primarily eliminated by the kidney. In healthy controls, drug that is not deposited in bone is rapidly excreted in the urine. Although clinical information is not available, animal studies suggest reduced drug clearance in renal failure. Alendronate is not recommended for use in patients with creatinine clearance less than 35 mL/min due to a lack of clinical experience in this setting. No dosage adjustment is necessary in patients with mild to moderate renal impairment (CrCl >= 35 mL/min).

References: