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Flutamide and Hemolysis

Result of checking the interaction of drug Flutamide and disease Hemolysis for safety when used together.

Check result:

Flutamide <> Hemolysis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Toxicity consistent with aniline exposure such as methemoglobinemia, hemolytic anemia, and cholestatic jaundice has been reported during flutamide therapy. Therapy with flutamide should be administered cautiously in patients with glucose-6-phosphate deficiency, hemoglobin M disease, and patients who smoke. Clinical monitoring of methemoglobin levels in susceptible individuals is recommended,

References:

Kouides PA, Abboud CN, Fairbanks VF "Flutamide-induced cyanosis refractory to methylene blue therapy." Br J Haematol 94 (1996): 73-5
"Product Information. Eulexin (flutamide)." Schering Laboratories, Kenilworth, NJ.
Schott AM, Vial T, Gozzo I, Chareyre S, Delmas PD "Flutamide-induced methemoglobinemia." DICP 25 (1991): 600-1

Flutamide

Generic Name: flutamide

Brand Name: Eulexin

Synonyms: n.a.

What is Flutamide?