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Fluphenazine Hydrochloride Injection and Renal dysfunction

Result of checking the interaction of drug Fluphenazine Hydrochloride Injection and disease Renal dysfunction for safety when used together.

Check result:

Fluphenazine Hydrochloride Injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Phenothiazines and their metabolites are excreted by the kidney. There are very limited data concerning the use of phenothiazines in patients with renal disease. Therapy with phenothiazines should be administered cautiously in patients with significantly impaired renal function. The manufacturers recommend periodic renal function tests for all patients during prolonged therapy.

References:

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McAllister CJ, Scowden EB, Stone WJ "Toxic psychosis induced by phenothiazine administration in patients with chronic renal failure." Clin Nephrol 10 (1978): 191-5
"Product Information. Vesprin (triflupromazine)" Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Tacaryl (methdilazine)." Westwood Squibb Pharmaceutical Corporation, Buffalo, NY.
"Product Information. Serentil (mesoridazine)" Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Sparine (promazine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
"Product Information. Torecan (thiethylperazine)" Roxane Laboratories Inc, Columbus, OH.
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Taylor G, Houston JB, Shaffer J, Mawer G "Pharmacokinetics of promethazine and its sulphoxide metabolite after intravenous and oral administration to man." Br J Clin Pharmacol 15 (1983): 287-93
"Product Information. Thorazine (chlorpromazine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Mellaril (thioridazine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
"Product Information. Compazine (prochlorperazine)." SmithKline Beecham, Philadelphia, PA.
"Product Information. Stelazine (trifluoperazine)" SmithKline Beecham, Philadelphia, PA.
"Product Information. Trilafon (perphenazine)" Schering Corporation, Kenilworth, NJ.
"Product Information. Temaril (trimeprazine)" Allergan Inc, Irvine, CA.
"Product Information. Prolixin (fluphenazine)." Bristol-Myers Squibb, Princeton, NJ.