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Fludara injection and Renal dysfunction

Result of checking the interaction of drug Fludara injection and disease Renal dysfunction for safety when used together.

Check result:

Fludara injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Fludarabine is primarily eliminated by the kidney and it should be administered cautiously in patients with renal insufficiency. Patients with moderate impairment of renal function (creatinine clearance 30 to 70 mL/min/1.73 m2) should have their fludarabine dose reduced by 20% and be monitored closely. Fludarabine is not recommended for patients with severely impaired renal function (creatinine clearance less than 30 mL/min/1.73 m2).

References:

Malspeis L, Grever MR, Staubus AE, Young D "Pharmacokinetics of 2-F-ara-A (9-B-D-Arabinofuranosyl-2-fluoroadenine) in cancer patients during the phase I clinical investigation of fludarabine phosphate." Semin Oncol 17 (1990): 18-32
"Product Information. Fludara (fludarabine)." Berlex, Richmond, CA.

Fludara injection

Generic Name: fludarabine

Brand Name: Fludara, Oforta

Synonyms: Fludara (injection), Fludara

What is Fludara injection?