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Fludara injection and Hemolytic anemia

Result of checking the interaction of drug Fludara injection and disease Hemolytic anemia for safety when used together.

Check result:

Fludara injection <> Hemolytic anemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Life-threatening and sometimes fatal autoimmune hemolytic anemia has been reported in patients with and without previous history of autoimmune hemolytic anemia or a positive Coombs' test during fludarabine therapy. Risk factors that predispose patients to this complication have not been identified. Patients should be instructed to immediately report signs and symptoms suggesting anemia such as fatigue, weakness, and/or bloody urine. Therapy with fludarabine should be administered cautiously in patients with anemia and those with a history of or a predisposition to hemolytic syndromes. Close clinical monitoring of hematopoietic function for hemolysis and anemia is recommended.

References:

"Product Information. Fludara (fludarabine)." Berlex, Richmond, CA.
Maclean R, Meiklejohn D, Soutar R "Fludarabine-related autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia." Br J Haematol 92 (1996): 768-9

Fludara injection

Generic Name: fludarabine

Brand Name: Fludara, Oforta

Synonyms: Fludara (injection), Fludara

What is Fludara injection?