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Floxuridine Injection and Dihydropyrimidine deficiency

Generic Name: floxuridine
Dosage Forms: n.a.
Other Brand Names: FUDR

Result of checking the interaction of drug Floxuridine Injection and disease Dihydropyrimidine deficiency for safety when used together.

Check result:

Floxuridine Injection <> Dihydropyrimidine deficiency

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

An inherited deficiency of dihydropyrimidine can alter the clearance of 5- FU and result in severe toxicity such as stomatitis, diarrhea, neutropenia and neurotoxicity. When administered as a continuous intra-arterial infusion, floxuridine (FUDR) is metabolized to FDUMP. However, with rapid intra-arterial injection, FUDR is metabolized to 5-FU. 5-FU requires metabolized to an inactive form by dihydropyrimidine dehydrogenase. FUDR should not be administered by rapid intra-arterial infusion to patients with dihydropyrimidine deficiency.

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