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Felbatol and Liver disease

Result of checking the interaction of drug Felbatol and disease Liver disease for safety when used together.

Check result:

Felbatol <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of felbamate is contraindicated in patients with a history of hepatic impairment. A marked increase in the incidence of hepatic failure, some resulting in fatality, has been associated with the use of felbamate relative to that expected in the general population (approximately 2000 cases per year). Currently, it is not known whether the risk is related to dose, duration of exposure, and/or concomitant use of other antiepileptic or hepatotoxic drugs. All patients treated with felbamate should have serum transaminase and bilirubin levels checked prior to initiating therapy and at 1- to 2-week intervals while treatment continues. Felbamate therapy should be withdrawn if abnormal liver function tests occur.

References:

Palmer KJ, McTavish D "Felbamate. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in epilepsy." Drugs 45 (1993): 1041-65
"Product Information. Felbatol (felbamate)." Wallace Laboratories, Cranbury, NJ.

Felbatol

Generic Name: felbamate

Brand Name: Felbatol

Synonyms: n.a.

What is Felbatol?