Drug search by name

Famciclovir and Liver disease

Result of checking the interaction of drug Famciclovir and disease Liver disease for safety when used together.

Check result:

Famciclovir <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Famciclovir is converted by the liver to the active antiviral metabolite, penciclovir. The bioavailability of penciclovir following a dose of famciclovir was not affected in patients with well-compensated chronic liver disease. However, there are no data on the pharmacokinetic disposition of famciclovir in patients with severe uncompensated liver disease. Therapy with famciclovir should be administered cautiously in these patients, since the clinical significance of possible famciclovir accumulation is unknown. Theoretically, famciclovir may also not be effective in these patients.

References:

Gill KS, Wood MJ "The clinical pharmacokinetics of famciclovir." Clin Pharmacokinet 31 (1996): 1-8
"Product Information. Famvir (famciclovir)." SmithKline Beecham, Philadelphia, PA.
Boike SC, Pue M, Audet PR, Freed MI, Fairless A, Ilson BE, Zariffa N, Jorkasky DK "Pharmacokinetics of famciclovir in subjects with chronic hepatic disease." J Clin Pharmacol 34 (1994): 1199-207
Perry CM, Wagstaff AJ "Famciclovir - a review of its pharmacological properties and therapeutic efficacy in herpesvirus infections." Drugs 50 (1995): 396-415

Famciclovir

Generic Name: famciclovir

Brand Name: Famvir

Synonyms: n.a.

What is Famciclovir?