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Ethosuximide Solution and Blood dyscrasias

Result of checking the interaction of drug Ethosuximide Solution and disease Blood dyscrasias for safety when used together.

Check result:

Ethosuximide Solution <> Blood dyscrasias

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hematologic toxicities, some with fatal outcome, have been associated with the use of succinimide anticonvulsants. Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenia, pancytopenia, and eosinophilia have been reported. Therapy with succinimide anticonvulsants should be administered cautiously in patients with preexisting blood dyscrasias and/or bone marrow suppression. Complete blood counts, including platelets, should be performed prior to initiating therapy and periodically during therapy. Marked depression of blood counts may be indication for withdrawal of succinimide therapy.

References:

"Product Information. Milontin (phensuximide)." Parke-Davis, Morris Plains, NJ.
"Product Information. Celontin Kapseals (methsuximide)." Parke-Davis, Morris Plains, NJ.
American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
"Product Information. Zarontin (ethosuximide)." Parke-Davis, Morris Plains, NJ.
Seip M "Aplastic anemia during ethosuximide medication. Treatment with bolus- methylprednisolone." Acta Paediatr Scand 72 (1983): 927-9
Massey GV, Dunn NL, Heckel JL, Myer EC, Russell EC "Aplastic anemia following therapy for absence seizures with ethosuximide." Pediatr Neurol 11 (1994): 59-61

Ethosuximide Solution

Generic Name: ethosuximide

Brand Name: Zarontin

Synonyms: Ethosuximide

What is Ethosuximide Solution?