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Ethosuximide Capsules and SLE

Result of checking the interaction of drug Ethosuximide Capsules and disease SLE for safety when used together.

Check result:

Ethosuximide Capsules <> SLE

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cases of systemic lupus erythematosus (SLE) have been reported in association with the use of succinimide anticonvulsants, primarily ethosuximide. Some of the patients recovered promptly following discontinuation of the drug, while others continued to have active disease long after. Therapy with succinimide anticonvulsants should be administered cautiously in patients with a history of SLE.

References:

Singsen BH, Fishman L, Hanson V "Antinuclear antibodies and lupus-like syndromes in children receiving anticonvulsants." Pediatrics 57 (1976): 529-34
Livingston S, Rodriguez H, Greene CA, Pauli LL "Systemic lupus erythematosus. Occurrence in association with ethosuximide therapy." JAMA 203 (1968): 731-2
Teoh PC, Chan HL "Lupus-scleroderma syndrome induced by ethosuximide." Arch Dis Child 50 (1975): 658-61
"Product Information. Celontin Kapseals (methsuximide)." Parke-Davis, Morris Plains, NJ.
Alter BP "Systemic lupus erythematosus and ethosuccimide." J Pediatr 77 (1970): 1093-5
"Product Information. Zarontin (ethosuximide)." Parke-Davis, Morris Plains, NJ.
Dabbous IA, Idriss HM "Occurrence of systemic lupus erythematosus in association with ethosuccimide therapy. Case report." J Pediatr 76 (1970): 617-20
"Product Information. Milontin (phensuximide)." Parke-Davis, Morris Plains, NJ.
Beernink DH, Miller JJ 3d "Anticonvulsant-induced antinuclear antibodies and lupus-like disease in children." J Pediatr 82 (1973): 113-7

Ethosuximide Capsules

Generic Name: ethosuximide

Brand Name: Zarontin

Synonyms: Ethosuximide

What is Ethosuximide Capsules?