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Ethacrynic Sodium Injection and Cirrhosis

Result of checking the interaction of drug Ethacrynic Sodium Injection and disease Cirrhosis for safety when used together.

Check result:

Ethacrynic Sodium Injection <> Cirrhosis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Loop diuretic therapy should be initiated in the hospital under strict observation in patients with liver cirrhosis and ascites. Sudden alteration of fluid and electrolyte balance may precipitate hepatic encephalopathy and coma in such patients, who are also at increased risk for the development of hypokalemia. Supplemental potassium and/or concomitant use of an aldosterone antagonist or potassium-sparing agent may help prevent hypokalemia and metabolic alkalosis. Loop diuretics should be withheld in patients with hepatic coma until the condition improves.

References:

"Product Information. Lasix (furosemide)." sanofi-aventis , Bridgewater, NJ.
Lieberman FL, Reynolds TB "The use of ethacrynic acid in patients with cirrhosis and ascites." Gastroenterology 49 (1965): 531-8
Schwartz FD, Pillay VK, Kark RM "Ethacrynic acid: its usefulness and untoward effects." Am Heart J 79 (1970): 427-8
Knauf H, Mutschler E "Liver cirrhosis with ascites: pathogenesis of resistance to diuretics and long-term efficacy and safety of torasemide." Cardiology 84 (1994): 87-98
"Product Information. Demedex (torsemide)." Boehringer Mannheim, Gaithersburg, MD.
"Product Information. Bumex (bumetanide)." Roche Laboratories, Nutley, NJ.
"Product Information. Edecrin (ethacrynic acid)." Merck & Co, Inc, West Point, PA.
Ring-Larsen H "Bumetanide in the treatment of hepatic ascites. A short and long-term study." Acta Med Scand 195 (1974): 411-4

Ethacrynic Sodium Injection

Generic Name: ethacrynic acid

Brand Name: Edecrin, Edecrin Sodium, Sodium Edecrin

Synonyms: Ethacrynic acid, Ethacrynic Acid

What is Ethacrynic Sodium Injection?