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Epoprostenol Sodium and CHF

Result of checking the interaction of drug Epoprostenol Sodium and disease CHF for safety when used together.

Check result:

Epoprostenol Sodium <> CHF

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of epoprostenol is contraindicated in patients with heart failure due to reduced severe left ventricular systolic dysfunction. A large study involving such patients was terminated after an interim analysis revealed a higher mortality in the group receiving epoprostenol plus standard therapy than in the group receiving standard therapy alone.

References:

Pickles H, O'Grady J "Side effects occurring during administration of epoprostenol (prostacyclin, PGI2), in man." Br J Clin Pharmacol 14 (1982): 177-85
"Product Information. Flolan (epoprostenol)." Glaxo Wellcome, Research Triangle Park, NC.
Bugiardini R, Galvani M, Ferrini D, Gridelli C, Tollemeto D, Macri N, Puddu P, Lenzi S "Myocardial ischemia during intravenous prostacyclin administration: hemodynamic findings and precautionary measures." Am Heart J 113 (1987): 234-40
"Epoprostenol for primary pulmonary hypertension." Med Lett Drugs Ther 38 (1996): 14-5
Bugiardini R, Galvani M, Ferrini D, Gridelli C, Tollemeto D, Mari L, Puddu P, Lenzi S "Myocardial ischemia induced by prostacyclin and iloprost." Clin Pharmacol Ther 38 (1985): 101-8

Epoprostenol Sodium

Generic Name: epoprostenol

Brand Name: Flolan, Veletri

Synonyms: Epoprostenol

What is Epoprostenol Sodium?