AccessPak for HIV PEP Expanded with Kaletra and Hepatotoxicity
Result of checking the interaction of drug AccessPak for HIV PEP Expanded with Kaletra and disease Hepatotoxicity for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Hepatotoxicity including lactic acidosis, severe hepatomegaly with steatosis, fulminant hepatitis, and hepatic failure has been associated with the use of some nucleoside reverse transcriptase inhibitors (NRTIs) alone or in combination with other antiretroviral agents. Therapy with NRTIs should be administered cautiously in patients with preexisting liver disease, a history of alcohol abuse, or hepatitis. Therapy should be suspended if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occur. The use of abacavir is contraindicated in patients with moderate to severe hepatic impairment as its safety and efficacy has not been established on these patients.
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Generic Name: emtricitabine / lopinavir / ritonavir / tenofovir
Brand Name: AccessPak for HIV PEP Expanded with Kaletra
Synonyms: n.a.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Hepatotoxicity, including jaundice, hepatitis and hepatic transaminase elevations exceeding five times the upper limit of normal, has been reported in patients receiving ritonavir alone and in combination with nucleoside reverse transcriptase inhibitors or other protease inhibitors. In addition, ritonavir is primarily metabolized by the liver and may accumulate in patients with hepatic impairment. Therapy with ritonavir should be administered cautiously in patients with preexisting liver disease, liver enzyme abnormalities, or hepatitis. Ritonavir is not recommended for patients with severe hepatic impairment.
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- "Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
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- Sommadossi JP "HIV protease inhibitors: pharmacologic and metabolic distinctions." AIDS 13 (1999): s29-40
- Pai VB, Koranyi K, Nahata MC "Acute hepatitis and bleeding possibly induced by zidovudine and ritonavir in an infant with HIV infection." Pharmacotherapy 20 (2000): 1135-40
Generic Name: emtricitabine / lopinavir / ritonavir / tenofovir
Brand Name: AccessPak for HIV PEP Expanded with Kaletra
Synonyms: n.a.
AccessPak for HIV PEP Expanded with Kaletra - hepatotoksyczność 
AccessPak for HIV PEP Expanded with Kaletra - hepatotoxicidade 
AccessPak for HIV PEP Expanded with Kaletra - hepatotoksisiti 
AccessPak for HIV PEP Expanded with Kaletra - hepatotoksisitas 
AccessPak for HIV PEP Expanded with Kaletra - epatotossicità 
AccessPak for HIV PEP Expanded with Kaletra - hépatotoxicité 
AccessPak for HIV PEP Expanded with Kaletra - Hepatotoxizität 
AccessPak for HIV PEP Expanded with Kaletra - hepatotoxicidad 
AccessPak for HIV PEP Expanded with Kaletra - гепатотоксичность 
AccessPak for HIV PEP Expanded with Kaletra - hepatotoksisite 
AccessPak for HIV PEP Expanded with Kaletra - السمية الكبدية 
AccessPak for HIV PEP Expanded with Kaletra - 肝毒性