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Eluxadoline and Hepatic impairment

Result of checking the interaction of drug Eluxadoline and disease Hepatic impairment for safety when used together.

Check result:

Eluxadoline <> Hepatic impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Eluxadoline is contraindicated in patients with severe hepatic impairment, as these patients are at risk for significantly increased plasma concentrations (16- fold), and there is no information to support the safety on these patients. In patients with mild to moderate hepatic impairment the plasma concentrations are increased to a lesser extent. It is recommended to decrease the dose to 75 mg twice a day on these patients and monitor regularly for impaired mental or physical abilities and for any other eluxadoline related adverse reactions.

Eluxadoline

Generic Name: eluxadoline

Brand Name: Viberzi

Synonyms: n.a.

What is Eluxadoline?