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Dtic-Dome and Renal dysfunction

Generic Name: dacarbazine
Dosage Forms: n.a.
Other Brand Names: Dtic-Dome

Result of checking the interaction of drug Dtic-Dome and disease Renal dysfunction for safety when used together.

Check result:

Dtic-Dome <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Dacarbazine is partially eliminated by the kidney via renal tubular secretion. Approximately 40% of dacarbazine is eliminated unchanged in the urine. The half-life of dacarbazine may be increased in patients with renal impairment. Rare reports of unspecified, severe renal toxicity has been noted. Therapy with dacarbazine should be administered cautiously to patients with compromised renal function. Clinical monitoring of renal function is recommended.

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