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Doxepin Tablets and Schizophrenia/bipolar disorder

Result of checking the interaction of drug Doxepin Tablets and disease Schizophrenia/bipolar disorder for safety when used together.

Check result:

Doxepin Tablets <> Schizophrenia/bipolar disorder

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Tricyclic antidepressants (TCAs) may aggravate symptoms of psychosis in schizophrenic patients, particularly those with paranoid symptomatology. Depressed patients, usually those with bipolar disorder, may experience a switch from depression to mania or hypomania. These occurrences have also been reported rarely with the tetracyclic antidepressant, maprotiline. Therapy with these agents should be administered cautiously in patients with schizophrenia, bipolar disorder, or a history of mania.

References:

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"Product Information. Sinequan (doxepin)." Roerig Division, New York, NY.
"Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.
"Product Information. Tofranil (imipramine)." Novartis Pharmaceuticals, East Hanover, NJ.
"Product Information. Surmontil (trimipramine)" Wyeth-Ayerst Laboratories, Philadelphia, PA.