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Doxepin Tablets and Liver/renal disease

Result of checking the interaction of drug Doxepin Tablets and disease Liver/renal disease for safety when used together.

Check result:

Doxepin Tablets <> Liver/renal disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

In general, tricyclic antidepressants should be used with caution in patients with liver or renal disease, as these drugs are metabolized and excreted through the liver and kidneys. Dose selection, especially in the elderly patients that might have liver or renal dysfunction, should usually be limited to the smallest effective total daily dose. Some tricyclic antidepressants such as clomipramine and nortriptyline have occasionally been associated with elevations in SGOT (AST) and SGPT (ALT), and other hepatic adverse events such as jaundice. Although serious liver injury has only been reported rarely, therapy with these drugs should be administered cautiously in patients with preexisting liver disease and periodic monitoring of liver enzyme levels is recommended.

References:

Larrey D, Rueff B, Pessayre D, Danan G, Algard M, Geneve J, Benhamou JP "Cross hepatotoxicity between tricyclic antidepressants." Gut 27 (1986): 726-7
"Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.

Doxepin Tablets

Generic Name: doxepin

Brand Name: Silenor, Sinequan, Sinequan

Synonyms: Doxepin (Sinequan), Doxepin (Systemic)

What is Doxepin Tablets?