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Doxepin Tablets and Bone marrow suppression

Result of checking the interaction of drug Doxepin Tablets and disease Bone marrow suppression for safety when used together.

Check result:
Doxepin Tablets <> Bone marrow suppression
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of tricyclic and tetracyclic antidepressants (TCAs) has rarely been associated with bone marrow suppression. Leukopenia, agranulocytosis, thrombocytopenia, anemia, eosinophilia, purpura, and pancytopenia have been reported with some TCAs. Patients with preexisting bone marrow suppression or blood dyscrasias receiving TCAs should be monitored closely during therapy for further decreases in blood counts.

References:
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  • "Product Information. Surmontil (trimipramine)" Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • "Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.
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  • "Product Information. Tofranil (imipramine)." Novartis Pharmaceuticals, East Hanover, NJ.
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  • "Product Information. Pamelor (nortriptyline)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
  • "Product Information. Norpramin (desipramine)." Hoechst Marion-Roussel Inc, Kansas City, MO.
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  • Hunt KA, Resnick MP "Clomipramine-induced agranulocytosis and its treatment with G-CSF." Am J Psychiatry 150 (1993): 522-3
  • Wolf B, Conradty M, Grohmann R, Ruther E, Witzgall H, Londong V "A case of immune complex hemolytic anemia, thrombocytopenia, and acute renal failure associated with doxepin use." J Clin Psychiatry 50 (1989): 99-100
  • "Product Information. Vivactil (protriptyline)" Merck & Co, Inc, West Point, PA.
Doxepin Tablets

Generic Name: doxepin

Brand Name: Silenor, Sinequan, Sinequan

Synonyms: Doxepin (Sinequan), Doxepin (Systemic)

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