Dolasetron Tablets and QT interval prolongation
Result of checking the interaction of drug Dolasetron Tablets and disease QT interval prolongation for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Dolasetron may cause acute but usually reversible and self-limiting interval changes in the electrocardiogram, including PR, QTc and JT prolongation and QRS widening. The incidence and severity of these changes are related to serum levels of the active metabolite, hydrodolasetron. Cardiovascular morbidity such as heart block and cardiac arrhythmias may occur rarely. Therapy with dolasetron should be administered cautiously in patients with or predisposed to prolongation of cardiac conduction intervals. Risk factors include hypokalemia; hypomagnesemia; use of diuretics that may induce electrolyte abnormalities; use of antiarrhythmic agents or other drugs that may cause QTc prolongation; cumulative high-dose anthracycline therapy; significant bradycardia; congestive heart failure; myocardial ischemia; and atrial fibrillation.
- "Product Information. Anzemet (dolasetron)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Generic Name: dolasetron
Brand Name: Anzemet
Synonyms: Dolasetron