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Dimetapp, Childrens Non-Drowsy Allergy ODT and Renal/liver disease

Result of checking the interaction of drug Dimetapp, Childrens Non-Drowsy Allergy ODT and disease Renal/liver disease for safety when used together.

Check result:

Dimetapp, Childrens Non-Drowsy Allergy ODT <> Renal/liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Loratadine is primarily converted by the liver to an active metabolite, and both parent drug and metabolite are excreted in the urine. Patients with renal and/or liver disease may be at greater risk for adverse effects from loratadine due to drug and metabolite accumulation. The manufacturer recommends one-half the regular dosage initially in patients with liver failure or decreased renal function (GFR < 30 mL/min). Due to the differential effects of hepatic impairment on the serum half-life and clearance of loratadine and pseudoephedrine, the use of products containing a fixed combination of these drugs is not recommended in the presence of liver failure.

References:

Monroe EW "Safety and efficacy of loratadine in urticaria." Int J Dermatol 35 (1996): 837-41
Matzke GR, Halstenson CE, Opsahl JA, Hilbert J, Perentesis G, Radwanski E, Zampaglione N "Pharmacokinetics of loratadine in patients with renal insufficiency." J Clin Pharmacol 30 (1990): 364-71
Clissold SP, Sorkin EM, Goa KL "Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy." Drugs 37 (1989): 42-57
Hilbert J, Moritzen V, Parks A, Radwanski E, Perentesis G, Symchowicz S, Zampaglione N "The pharmacokinetics of loratadine in normal geriatric volunteers." J Int Med Res 16 (1988): 50-60
"Product Information. Claritin (loratadine)." Schering Laboratories, Kenilworth, NJ.
Schiano TD, Bellary SV, Cassidy MJ, Thomas RM, Black M "Subfulminant liver failure and severe hepatotoxicity caused by loratadine use." Ann Intern Med 125 (1996): 738-40

Dimetapp, Childrens Non-Drowsy Allergy ODT

Generic Name: loratadine

Brand Name: Alavert, Claritin, Claritin Reditab, Clear-Atadine, Dimetapp ND, Ohm Allergy Relief, QlearQuil All Day & Night, Tavist ND, Wal-itin

Synonyms: Dimetapp ND

What is Dimetapp, Childrens Non-Drowsy Allergy ODT?