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Dilantin injection and Osteomalacia

Result of checking the interaction of drug Dilantin injection and disease Osteomalacia for safety when used together.

Check result:

Dilantin injection <> Osteomalacia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Phenytoin may interfere with vitamin D metabolism. Hypocalcemia and osteomalacia have been reported. Therapy with phenytoin should be administered cautiously in patients with preexisting vitamin D deficiency. The same precaution should also be observed with other hydantoin anticonvulsants (i.e. ethotoin and mephenytoin) because of their structural and pharmacological similarities to phenytoin.

References:

Anast CS "Anticonvulsant drugs and calcium metabolism." N Engl J Med 292 (1975): 587-8
Schmitt BP, Nordlund DJ, Rodgers LA "Prevalence of hypocalcemia and elevated serum alkaline phosphatase in patients receiving chronic anticonvulsant therapy." J Fam Pract 18 (1984): 873-7
"Product Information. Cerebyx (fosphenytoin)." Parke-Davis, Morris Plains, NJ.
Siddiqui MA "Osteomalacia and phenytoin therapy." Ann Intern Med 121 (1994): 550
Ronin DI, Wu Y, Sahgal V, MacLean IC "Intractable muscle pain syndrome, osteomalacia, and axonopathy in long-term use of phenytoin." Arch Phys Med Rehabil 72 (1991): 755-8
Bell RD, Pak CY, Zerwekh J, et al "Effect of phenytoin on bone and vitamin d metabolism." Ann Neurol 5 (1979): 374-8
"Product Information. Dilantin (phenytoin)." Parke-Davis, Morris Plains, NJ.
Alderman CP, Hill CL "Abnormal bone mineral metabolism after long-term anticonvulsant treatment." Ann Pharmacother 28 (1994): 47-8
Hahn TJ, Hendin BA, Scharp CR, Haddad JG "Effect of chronic anticonvulsant therapy on serum 25-hydroxycalciferol levels in adults." N Engl J Med 287 (1972): 900-4

Dilantin injection

Generic Name: phenytoin

Brand Name: Dilantin, Phenytek, Dilantin Infatabs, Phenytoin Sodium, Prompt

Synonyms: Dilantin

What is Dilantin injection?