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Digoxin oral/injection and Hyperthyroidism

Result of checking the interaction of drug Digoxin oral/injection and disease Hyperthyroidism for safety when used together.

Check result:

Digoxin oral/injection <> Hyperthyroidism

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Heart failure and/or atrial arrhythmias resulting from hypermetabolic or hyperdynamic states such as hyperthyroidism, hypoxia, or arteriovenous shunt are best managed by treating the underlying condition. Atrial arrhythmias associated with hypermetabolic states are particularly refractory to digoxin, possibly due to altered pharmacokinetics. Specifically, the apparent volume of distribution and renal elimination of the drug may be increased, resulting in lower serum concentrations. Therapy with digoxin should be administered cautiously in patients with hyperthyroidism. Serum digoxin levels should be monitored regularly and dosage adjustments may be required secondary to changes in their thyroid condition.

References:

Lawrence JR, Sumner DJ, Kalk WJ, et al "Digoxin kinetics in patients with thyroid dysfunction." Clin Pharmacol Ther 22 (1977): 7-13
"Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Bonelli J, Haydl H, Hruby K, Kaik G "The pharmacokinetics of digoxin in patients with manifest hyperthyroidism and after normalization of thyroid function." Int J Clin Pharmacol Biopharm 16 (1978): 302-6
O'Connor P, Feely J "Clinical pharmacokinetics and endocrine disorders. Therapeutic implications." Clin Pharmacokinet 13 (1987): 345-64
Ochs HR, Greenblatt DJ, Bodem G, Dengler HJ "Disease-related alterations in cardiac-glycoside disposition." Clin Pharmacokinet 7 (1982): 434-51

Digoxin oral/injection

Generic Name: digoxin

Brand Name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin oral/injection?