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Digoxin Intravenous and Ventricular arrhythmia

Result of checking the interaction of drug Digoxin Intravenous and disease Ventricular arrhythmia for safety when used together.

Check result:

Digoxin Intravenous <> Ventricular arrhythmia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of digoxin is contraindicated in patients with ventricular fibrillation. Digoxin toxicity is associated with adverse cardiac effects, including ventricular arrhythmias, which are most commonly seen in chronic toxicity. Digoxin-induced ventricular tachycardia is associated with a high mortality rate, since ventricular fibrillation or asystole may result. Therapy with digoxin should be administered cautiously in patients with frequent ventricular premature contractions or ventricular tachycardia, especially if these arrhythmias are not caused by heart failure.

References:

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Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, eds. "Harrison's Principles of Internal Medicine. 14th ed." New York, NY: McGraw-Hill Health Professionals Division (1998):
Moorman JR, Pritchett EL "The arrhythmias of digitalis intoxication." Arch Intern Med 145 (1985): 1289-92
Chung EK "Digitalis-induced cardiac arrhythmias: a report of 180 cases." Jpn Heart J 10 (1969): 409-27
Manninen V, Reissell P, Paukkala E "Transient cardiac arrhythmias after single daily maintenance doses of digoxin." Clin Pharmacol Ther 20 (1976): 266-8
"Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Warren JL, Mcbean AM, Hass SL, Babish JD "Hospitalizations with adverse events caused by digitalis therapy among elderly medicare beneficiaries." Arch Intern Med 154 (1994): 1482-7
Steiner JF, Robbins LJ, Hammermeister KE, Roth SC, Hammond WS "Incidence of digoxin toxicity in outpatients." West J Med 161 (1994): 474-8
Salmela PI, Ikaheimo M, Juustila H "Fatal ventricular fibrillation after treatment with digoxin in a 27- year-old man with mitral leaflet prolapse syndrome." Br Heart J 46 (1981): 338-41

Digoxin Intravenous

Generic Name: digoxin

Brand Name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digoxin Intravenous?