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Digitaline Nativelle and Hypothyroidism

Result of checking the interaction of drug Digitaline Nativelle and disease Hypothyroidism for safety when used together.

Check result:

Digitaline Nativelle <> Hypothyroidism

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hypothyroidism may reduce the requirements for digoxin due to decreased volume of distribution and plasma clearance of the drug. Therapy with digoxin should be initiated at lower dosages in patients with hypothyroidism to avoid toxicity. Serum digoxin levels should be monitored regularly and dosage adjustments may be required secondary to changes in thyroid condition.

References:

O'Connor P, Feely J "Clinical pharmacokinetics and endocrine disorders. Therapeutic implications." Clin Pharmacokinet 13 (1987): 345-64
"Product Information. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Ochs HR, Greenblatt DJ, Bodem G, Dengler HJ "Disease-related alterations in cardiac-glycoside disposition." Clin Pharmacokinet 7 (1982): 434-51
Lawrence JR, Sumner DJ, Kalk WJ, et al "Digoxin kinetics in patients with thyroid dysfunction." Clin Pharmacol Ther 22 (1977): 7-13

Digitaline Nativelle

Generic Name: digoxin

Brand Name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: Digoxin

What is Digitaline Nativelle?