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Delafloxacin oral/injection and Renal impairment

Result of checking the interaction of drug Delafloxacin oral/injection and disease Renal impairment for safety when used together.

Check result:

Delafloxacin oral/injection <> Renal impairment

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

The use of delafloxacin is not recommended in patients with End Stage Renal Disease (ESRD). In patients with severe renal impairment or ESRD, accumulation of the intravenous vehicle, sulfobutylether-beta-cyclodextrin (SBECD) occurs. No dosage adjustment is necessary in patients with mild or moderate renal impairment. The dose of delafloxacin intravenous IV infusion in patients with severe renal impairment should be decreased to 200 mg intravenously every 12 hours; the oral dose in patients with severe renal impairment is 450 mg orally every 12 hours. It is recommended to closely monitor serum creatinine in patients with severe renal impairment receiving intravenous delafloxacin and if serum creatinine level increases, consideration should be given to changing to the oral form of delafloxacin. If eGFR decreases to <15 mL/min/1.73 m2, the drug should be discontinued.

Delafloxacin oral/injection

Generic Name: delafloxacin

Brand Name: Baxdela

Synonyms: Delafloxacin (oral/injection), Delafloxacin

What is Delafloxacin oral/injection?