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Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate and Hemophilia

Result of checking the interaction of drug Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate and disease Hemophilia for safety when used together.

Check result:

Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate <> Hemophilia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

There have been postmarketing reports of increased bleeding, including spontaneous skin hematomas and hemarthrosis, in types A and B hemophiliac patients treated with protease inhibitors. However, a causal relationship has not been established. In some patients, additional Factor VIII was given. In more than half of the reported cases, protease inhibitor therapy was continued or reintroduced following an interruption. Hemophiliacs and patients with other coagulation defects should be monitored closely for bleeding during protease inhibitor therapy.

References:

"Product Information. Crixivan (indinavir)." Merck & Co, Inc, West Point, PA.
"Product Information. Kaletra (lopinavir-ritonavir)" Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Agenerase (amprenavir)." Glaxo Wellcome, Research Triangle Pk, NC.
"Product Information. Viracept (nelfinavir)." Agouron Pharma Inc, La Jolla, CA.
"Product Information. Invirase (saquinavir)." Roche Laboratories, Nutley, NJ.
"Product Information. Norvir (ritonavir)." Abbott Pharmaceutical, Abbott Park, IL.
"Product Information. Lexiva (fosamprenavir)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Aptivus (tipranavir)." Boehringer-Ingelheim, Ridgefield, CT.
"Product Information. Fortovase (saquinavir)" Roche Laboratories, Nutley, NJ.

Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate

Generic Name: cobicistat / darunavir / emtricitabine / tenofovir alafenamide

Brand Name: Symtuza

Synonyms: Cobicistat, darunavir, emtricitabine, and tenofovir, Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide

What is Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate?