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Danaparoid and Peptic ulcer disease

Result of checking the interaction of drug Danaparoid and disease Peptic ulcer disease for safety when used together.

Check result:

Danaparoid <> Peptic ulcer disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Anticoagulants are contraindicated in patients with active major bleeding or those patients at risk for hemorrhage. Hemorrhage due to heparin derivatives may be treated with protamine sulfate 1%. However, protamine sulfate may not completely neutralize the anti- Factor Xa activity.

References:

"Product Information. Fragmin (dalteparin)." Pharmacia and Upjohn, Kalamazoo, MI.
"Product Information. Heparin Sodium (heparin)." Lilly, Eli and Company, Indianapolis, IN.
"Product Information. Lovenox (enoxaparin)." Rhone-Poulenc Rorer, Collegeville, PA.
Hirsh J, Fuster V "Guide to anticoagulant therapy. 1. Heparin." Circulation 89 (1994): 1449-68
"Product Information. Orgaran (danaparoid)." Organon, West Orange, NJ.
Nieuwenhuis HK, Albada J, Banga JD, Sixma JJ "Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin." Blood 78 (1991): 2337-43
Sugiyama T, Itoh M, Ohtawa M, Natsuga T "Study on neutralization of low molecular weight heparin (LHG) by protamine sulfate and its neutralization characteristics." Thromb Res 68 (1992): 119-29
Walker AM, Jick H "Predictors of bleeding during heparin therapy." JAMA 244 (1980): 1209-12
Oates JA, Wood AJJ "Heparin." N Engl J Med 324 (1991): 1565-74
Nieuwenhuis HK, Albada J, Banga JD, Sixma JJ "Identification of risk factors for bleeding during treatment of acute venous thromboembolism with heparin or low molecular weight heparin." Blood 78 (1991): 2337-43
Breddin HK "Low molecular weight heparins and bleeding." Semin Thromb Hemost 15 (1989): 401-4