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Dacarbazine and Myelosuppression

Generic Name: dacarbazine
Dosage Forms: n.a.
Other Brand Names: Dtic-Dome

Result of checking the interaction of drug Dacarbazine and disease Myelosuppression for safety when used together.

Check result:

Dacarbazine <> Myelosuppression

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Dacarbazine is myelosuppressive, primarily affecting leukocytes and thrombocytes, although anemia occasionally occurs. Deaths due to myelosuppression have been reported. Patients should be instructed to immediately report any signs or symptoms suggesting bone marrow suppression such as fever, sore throat, local infection, or bleeding. Therapy with dacarbazine should be withheld or extreme caution exercised when administered in patients whose bone marrow reserve may be severely depressed. Close clinical monitoring of hematopoietic function is recommended.

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