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Coumadin Injection and Renal dysfunction

Result of checking the interaction of drug Coumadin Injection and disease Renal dysfunction for safety when used together.

Check result:

Coumadin Injection <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

There is no evidence that hypoprothrombinemic response to oral anticoagulants (coumarin and indandione derivatives) is altered in renal impairment due to decreased plasma protein binding, thus dosage adjustments are generally not necessary. However, patients with renal impairment may demonstrate platelet defects and may be at increased risk for bleeding. Therapy with oral anticoagulants should be administered cautiously in patients with severe or moderate renal dysfunction. The INR should be monitored closely, and patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References:

Bachmann K, Shapiro R, Mackiewicz J "Warfarin elimination and responsiveness in patients with renal dysfunction." J Clin Pharmacol 17 (1977): 292-9
Yacobi A, Udall JA, Levy G "Serum protein binding as a determinant of warfarin body clearance and anticoagulant effect." Clin Pharmacol Ther 19 (1976): 552-8
Landfeld CS, Goldman L "Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy." Am J Med 87 (1989): 144-52
Demirkan K, Stephens MA, Newman KP, Self TH "Response to warfarin and other oral anticoagulants: effects of disease states." South Med J 93 (2000): 448-54; quiz 455
Landefeld CS, Cook EF, Flatley M, Weisberg M, Goldman L "Identification and preliminary validation of predictors of major bleeding in hospitalized patients starting anticoagulant therapy." Am J Med 82 (1987): 703-13
Bachmann K, Shapiro R, Mackiewicz J "Influence of renal dysfunction on warfarin plasma protein binding." J Clin Pharmacol 16 (1976): 468-72
"Product Information. Coumadin (warfarin)." DuPont Pharmaceuticals, Wilmington, DE.
Shetty HG, Fennerty AG, Routledge PA "Clinical pharmacokinetic considerations in the control of oral anticoagulant therapy." Clin Pharmacokinet 16 (1989): 238-53

Coumadin Injection

Generic Name: warfarin

Brand Name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?