Drug search by name

Coumadin Injection and Increased response

Result of checking the interaction of drug Coumadin Injection and disease Increased response for safety when used together.

Check result:

Coumadin Injection <> Increased response

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Patients with a collagen vascular disease (e.g., systemic lupus erythematosus, rheumatoid arthritis, scleroderma), congestive heart failure (especially decompensated disease), severe or prolonged diarrhea, fever, hyperthyroidism, malabsorption, or steatorrhea may exhibit greater than expected hypoprothrombinemic response to oral anticoagulants. Thus, more frequent laboratory (PT/INR) monitoring and dosage adjustment of anticoagulant may be required based on changes in the patient's condition. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References:

"Product Information. Coumadin (warfarin)." DuPont Pharmaceuticals, Wilmington, DE.
Vagenakis AG, Cote R, Miller ME, et al "Enhancement of warfarin-induced hypoprothrombinemia by thyrotoxicosis." Johns Hopkins Med J 131 (1972): 69-73
Landefeld CS, Cook EF, Flatley M, Weisberg M, Goldman L "Identification and preliminary validation of predictors of major bleeding in hospitalized patients starting anticoagulant therapy." Am J Med 82 (1987): 703-13
Black JA "Diarrhoea, vitamin k, and warfarin." Lancet 344 (1994): 1373
Smith JK, Aljazairi A, Fuller SH "INR elevation associated with diarrhea in a patient receiving warfarin." Ann Pharmacother 33 (1999): 301-4
Kellett HA, Sawers JS, Boulton FE, Cholerton S, Park BK, Toft AD "Problems of anticoagulation with warfarin in hyperthyroidism." Q J Med 58 (1986): 43-51
Owens JC, Neely WB, Owen WR "Effect of sodium dextrothyroxine in patients receiving anticoagulants." N Engl J Med 266 (1962): 76-9
Demirkan K, Stephens MA, Newman KP, Self TH "Response to warfarin and other oral anticoagulants: effects of disease states." South Med J 93 (2000): 448-54; quiz 455
Self TH, Straughn AB, Weisburst MR "Effect of hyperthryroidism on hypoprothrombinemic response to warfarin." Am J Hosp Pharm 33 (1976): 387-9
Self T, Weisburst M, Wooten E, Straughn A, Oliver J "Warfarin-induced hypoprothrombinemia: potentiation by hyperthyroidism." JAMA 231 (1975): 1165-6

Coumadin Injection

Generic Name: warfarin

Brand Name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?