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Coumadin Injection and Decreased response

Result of checking the interaction of drug Coumadin Injection and disease Decreased response for safety when used together.

Check result:

Coumadin Injection <> Decreased response

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Patients with edema, hereditary coumarin resistance, hyperlipidemia, hypothyroidism, or nephrotic syndrome may exhibit lower than expected hypoprothrombinemic response to oral anticoagulants. Thus, more frequent laboratory (PT/INR) monitoring and dosage adjustment of anticoagulant may be required based on changes in the patient's condition.

References:

Ganeval D, Fischer AM, Barre J, et al "Pharmacokinetics of warfarin in the nephrotic syndrome and effect on vitamin K-dependent clotting factors." Clin Nephrol 25 (1986): 75-80
Rice AJ, McIntosh TJ, Fouts JR, et al "Decrease sensitivity to warfarin in patients with myxedema." Am J Med Sci 262 (1971): 211-5
"Product Information. Coumadin (warfarin)." DuPont Pharmaceuticals, Wilmington, DE.
Stephens MA, Self TH, Lancaster D, Nash T "Hypothyroidism: effect on warfarin anticoagulation." South Med J 82 (1989): 1585-6
Demirkan K, Stephens MA, Newman KP, Self TH "Response to warfarin and other oral anticoagulants: effects of disease states." South Med J 93 (2000): 448-54; quiz 455
Walters MB "The relationship between thyroid function and anticoagulant therapy." Am J Cardiol 11 (1963): 112-4

Coumadin Injection

Generic Name: warfarin

Brand Name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?