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Cobimetinib Fumarate and Cardiomyopathy

Result of checking the interaction of drug Cobimetinib Fumarate and disease Cardiomyopathy for safety when used together.

Check result:
Cobimetinib Fumarate <> Cardiomyopathy
Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Cardiomyopathy, defined as symptomatic and asymptomatic decline in left ventricular ejection fraction (LVEF), can occur with the use of cobimetinib. Evaluate LVEF prior to, 1 month after initiation, and every 3 months thereafter until discontinuation of cobimetinib. It is recommended to manage events of left ventricular dysfunction through treatment interruption, dose reduction, or discontinuation of therapy. If restarting cobimetinib after a dose reduction or interruption it is recommended to evaluate LVEF as clinically indicated. Care should be exercised when using cobimetinib as the safety of cobimetinib has not been established in patients with a baseline LVEF that is either below institutional lower limit of normal (LLN) or below 50%.

Cobimetinib Fumarate

Generic Name: cobimetinib

Brand Name: Cotellic

Synonyms: Cobimetinib

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