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Clozaril and Renal dysfunction

Result of checking the interaction of drug Clozaril and disease Renal dysfunction for safety when used together.

Check result:

Clozaril <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Clozapine is extensively metabolized by the liver and subsequently excreted in the urine (50%) and feces (35%), primarily as metabolites. One of the metabolites appears to have only limited pharmacologic activity, while the others are inactive. However, the effects of possible metabolite accumulation have not been studied. The manufacturer recommends that therapy with clozapine be administered cautiously in patients with impaired renal function.

References:

Jann MW, Grimsley SR, Gray EC, Chang WH "Pharmacokinetics and pharmacodynamics of clozapine." Clin Pharmacokinet 24 (1993): 161-76
"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.

Clozaril

Generic Name: clozapine

Brand Name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Clozaril?