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Clozaril and Hyperglycemia

Result of checking the interaction of drug Clozaril and disease Hyperglycemia for safety when used together.

Check result:

Clozaril <> Hyperglycemia

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Severe hyperglycemia, sometimes resulting in ketoacidosis, has been reported during clozapine treatment in patients with no prior history of hyperglycemia. Glucose levels normalized in most cases following discontinuation of clozapine, and a rechallenge in one patient produced a recurrence of hyperglycemia. While a causal relationship has not been established, patients with or predisposed to hyperglycemia should be monitored during clozapine therapy. Dosage adjustments in insulin or oral hypoglycemic medications may be necessary in patients with diabetes.

References:

Wehring H, Alexander B, Perry PJ "Diabetes mellitus associated with clozapine therapy." Pharmacotherapy 20 (2000): 844-7
"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.

Clozaril

Generic Name: clozapine

Brand Name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Clozaril?