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Clozaril and Hepatitis

Result of checking the interaction of drug Clozaril and disease Hepatitis for safety when used together.

Check result:

Clozaril <> Hepatitis

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Hepatitis has been reported in association with the use of clozapine, both in patients with and without underlying liver function abnormalities. Therapy with clozapine should be administered cautiously in patients with preexisting liver disease. The drug should be discontinued if clinically significant elevations of liver function tests or symptoms of jaundice occur.

References:

Kellner M, Wiedemann K, Krieg JC, Berg PA "Toxic hepatitis by clozapine treatment." Am J Psychiatry 150 (1993): 985-6
Grohmann R, Ruther E, Sassim N, Schmidt LG "Adverse effects of clozapine." Psychopharmacology (Berl) 99 (1989): s101-4
Marinkovic D, Timotijevic I, Babinski T, Totic S, Paunovic VR "The side-effects of clozapine: a four year follow-up study." Prog Neuropsychopharmacol Biol Psychiatry 18 (1994): 537-44
"Product Information. Clozaril (clozapine)." Novartis Pharmaceuticals, East Hanover, NJ.

Clozaril

Generic Name: clozapine

Brand Name: Clozaril, Fazaclo, Versacloz, Clopine, CloZAPine Synthon, Denzapine, Zaponex

Synonyms: n.a.

What is Clozaril?