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Clonidine Extended-Release Tablets and Renal dysfunction

Result of checking the interaction of drug Clonidine Extended-Release Tablets and disease Renal dysfunction for safety when used together.

Check result:

Clonidine Extended-Release Tablets <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Clonidine is primarily eliminated unchanged by the kidney. The serum concentrations and half-life of clonidine may be increased in patients with impaired renal function, so patients may benefit from a lower initial dose. Dosage adjustments may be necessary and modifications should be based on the degree of renal impairment. Only a minimal amount of clonidine is removed during routine hemodialysis, and there is no need to give supplemental clonidine following dialysis.

References:

"Product Information. Catapres (clonidine)." Boehringer-Ingelheim, Ridgefield, CT.
Hulter HN, Licht JH, Ilnicki LP, Singh S "Clinical efficacy and pharmacokinetics of clonidine in hemodialysis and renal insufficiency." J Lab Clin Med 94 (1979): 223-31
Lowenthal DT, Affrime MB, Meyer A, et al "Pharmacokinetics and pharmacodynamics of clonidine in varying states of renal function." Chest 83 (1983): 386-90

Clonidine Extended-Release Tablets

Generic Name: clonidine

Brand Name: Catapres, Kapvay, Catapres-TTS, Duraclon, Catapres-TTS-1, Catapres-TTS-2, Catapres-TTS-3

Synonyms: Clonidine, CloNIDine

What is Clonidine Extended-Release Tablets?