Adrucil and Dihydropyrimidine dehydrogenase deficiency
Result of checking the interaction of drug Adrucil and disease Dihydropyrimidine dehydrogenase deficiency for safety when used together.
When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.
Consumer:Fluorouracil is metabolized to an inactive form by dihydropyrimidine dehydrogenase. Inherited deficiency of this enzyme results in decreased clearance of 5-FU and severe toxicity such as stomatitis, diarrhea, neutropenia, and neurotoxicity. Rechallenge with dosage reduction resulted in recurrence and progression of toxicity. Therapy with fluorouracil should not be administered to patients with dihydropyrimidine deficiency.
- "Product Information. Fluorouracil Injection (fluorouracil)." Roche, Nutley, NJ.
Generic Name: fluorouracil
Brand Name: Adrucil
Synonyms: Adrucil (injection)
Adrucil - niedobór dehydrogenazy dihydropirymidyny 
Adrucil - deficiência de dihidropirimidina desidrogenase 
Adrucil - kekurangan dihidroprimidin dehidrogenase 
Adrucil - defisiensi dihydropyrimidine dehydrogenase 
Adrucil - deficit di diidropirimidina deidrogenasi 
Adrucil - déficit en dihydropyrimidine déshydrogénase 
Adrucil - Dihydropyrimidin-Dehydrogenase-Mangel 
Adrucil - deficiencia de dihidropirimidina deshidrogenasa 
Adrucil - дефицит дигидропиримидиндегидрогеназы 
Adrucil - dihidropirimidin dehidrojenaz eksikliği 
Adrucil - نقص نازعة هيدروجين ديهيدروبيريميدين 
Adrucil - 二氢嘧啶脱氢酶缺乏症