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Cleocin and Liver disease

Result of checking the interaction of drug Cleocin and disease Liver disease for safety when used together.

Check result:

Cleocin <> Liver disease

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Clindamycin is primarily metabolized by the liver. The serum concentration of clindamycin may be increased and the half-life prolonged in patients with severely impaired hepatic function. In addition, jaundice and liver enzyme abnormalities may occur during use of the drug. Therapy with clindamycin should be administered cautiously in patients with liver disease. Dosage adjustments may not be necessary when administered every 8 hours. However, serum concentrations should be monitored during high-dose therapy, and periodic liver function tests should be performed during prolonged therapy.

References:

"Product Information. Cleocin (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
Eng RH, Gorski S, Person A, et al "Clindamycin elimination in patients with liver disease." J Antimicrob Chemother 8 (1981): 277-81
Avant GR, Schenker S, Alford RH "The effect of cirrhosis on the disposition and elimination of clindamycin." Dig Dis 20 (1975): 223-30
Hinthorn DR, Baker LH, Romig DA, et al "Use of clindamycin in patients with liver disease." Antimicrob Agents Chemother 9 (1976): 498-501

Cleocin

Generic Name: clindamycin

Brand Name: Cleocin, Cleocin Pediatric, Cleocin HCl, Cleocin Phosphate, Cleocin Phosphate ADD-Vantage, Clindesse, ClindaMax Vaginal

Synonyms: n.a.

What is Cleocin?