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Clarithromycin Oral Suspension and Renal dysfunction

Result of checking the interaction of drug Clarithromycin Oral Suspension and disease Renal dysfunction for safety when used together.

Check result:

Clarithromycin Oral Suspension <> Renal dysfunction

Relevance: 23.07.2019 Reviewer: Shkutko P.M., M.D., in

When checking interaction based on authoritative sources Drugs.com, Rxlist.com, Webmd.com, Medscape.com there are contraindications or side effects that may cause harm or increase the negative effect from drug use in presence of concomitant diseases.

Consumer:

Clarithromycin and its primary, active metabolite are both eliminated by the kidney to some extent. The daily dosage should be halved in patients with severe renal impairment (CrCl < 30 mL/min). Dosage adjustments are usually not necessary in patients with mild to moderate renal impairment, although theoretically, drug accumulation could occur in these patients if they have concomitant liver disease.

References:

Hardy D, Guay D, Jones R "Clarithromycin, a unique macrolide." Diagn Microbiol Infect Dis 15 (1992): 39-53
Zuckerman JM, Kaye KM "The newer macrolides: azithromycin and clarithromycin." Infect Dis Clin North Am 9 (1995): 731-45
Peters D, Clissold S "Clarithromycin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential." Drugs 44 (1992): 117-64
Davey PG "The pharmacokinetics of clarithromycin and its 14-OH metabolite." J Hosp Infect 19 (1991): 29-37
Ferrero JL, Bopp BA, Marsh KC, et al "Metabolism and disposition of clarithromycin in man." Drug Metab Dispos 18 (1990): 441-6
"Product Information. Biaxin (clarithromycin)." Abbott Pharmaceutical, Abbott Park, IL.
Chu S, Wilson DS, Deaton RL, Mackenthun AV, Eason CN, Cavanaugh JH "Single- and multiple-dose pharmacokinetics of clarithromycin, a new macrolide antimicrobial." J Clin Pharmacol 33 (1993): 719-26

Clarithromycin Oral Suspension

Generic Name: clarithromycin

Brand Name: Biaxin, Biaxin XL

Synonyms: Clarithromycin

What is Clarithromycin Oral Suspension?